AUTHOR: Concepción Serrano López-Terradas, Instituto de Ciencia de Materiales de Madrid
WHEN: Thursday, January, 8 - 12 PM
WHERE: Salón de Actos, ICMM
ABSTRACT: Piezo4Spine is a multidisciplinary European project devoted to the development of effective therapeutics for neural repair after spinal cord injury (SCI). Over fifteen million people live and deal with the devastating consequences of SCI worldwide, being the cure for these patients still a mirage. In the Piezo4Spine project, we intend to build a 3D therapeutic mesh able to deliver multiple pro-regenerative signals to the injured spinal tissue to overcome inhibitory processes and activate tissue repair. Some of the building blocks for this theramesh include iron oxide nanoparticles, natural hydrogels and reduced graphene oxide scaffolds. Motor training routines are included to synergistically potentiate the benefits of the theramesh. These materials are all explored in vitro with primary cultures of neural cells from rat embryonic cerebral cortices and in vivo in cervical hemisected and thoracic transected rats. This talk will provide a journey through some of the most relevant findings of this research.
