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Through this ICMM space slack account you will be able to navigate the funk, padel, soccer, dance, articles-icmm, scientic-questions channel and many other things such as helping the new icmm-nautas. You can also open your own #channel to find people who share your interests. Join us! Read more

About

The Instituto de Ciencia de Materiales de Madrid (ICMM) is an institute of the Consejo Superior de Investigaciones Cientificas (CSIC) (Spanish National Research Council) founded in December 1986, that belongs to the Area of Science and Technology of Materials, one of the eight Areas in which the CSIC divides its research activities.

 

Our mission is to create new fundamental and applied knowledge in materials of high technological impact, their processing and their transfer to the productive sectors at local, national and European scales (the true value of materials is in their use), the training of new professionals, and the dissemination of the scientific knowledge.

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ICMM Congress

Forthcoming Events

JAN23/12:00

Exploring the metal-insulator transition in vanadium oxide thin films
Mariela Menghini  read more

JAN27/12:00

Materiales Ferroicos y Fenómenos de Spin
  read more

Tc‑,90Y‑, and 177Lu-Labeled Iron Oxide Nanoflowers Designed forPotential Use in Dual Magnetic Hyperthermia/Radionuclide CancerTherapy and Diagnosis

Ognjanovic, Milos; Radovic, M ; Mirkovic, M ; Prijovic, Z ; Morales, MD; Ceh, M ; Vranjes-Duric, S ; Antic, B

Development of a complex based on iron oxide nanoparticles (IONPs) for diagnosis and dual magnetic hyperthermia/radionuclide cancer therapy accomplishing high yields of radiolabeling and great magnetic heat induction is still a challenge. We report here the synthesis of citric acid, poly(acrylic acid) (PAA) and poly(ethylene glycol) coated IONPs and their labeling with three radionuclides, namely, technetium (Tc-99m), yttrium (Y-90), and lutetium (Lu-177), aiming at potential use in cancer diagnosis and therapy. Polyolsynthesized IONPs are a flowerlike structure with 13.5 nm spherically shaped cores and 24.8 nm diameter. PAA-coated nanoparticles (PAA@IONP) showed the best characteristics such as easy radiolabeling with very high yields (>97.5%) with all three radionuclides, and excellent in vitro stabilities with less than 10% of radionuclides detaching after 24 h. Heating ability of PAA@IONP in an alternating external magnetic field showed intrinsic loss power value of 7.3 nH m(2)/kg, which is one of higher reported values. Additionally, PAA@IONP itself presented no significant cytotoxicity to the CT-26 cancer cells, reaching IC50 at 60 mu g/mL. However, under the external magnetic field, they show hyperthermia-mediated cells killing, which correlated with the magnetic field strength and time of exposure. Since PAA@IONP are easy to prepare, biocompatible, and with excellent magnetic heat induction, these nanoparticles radiolabeled with high-energy beta emitters Y-90 and Lu-177 have valuable potential as agent for dual magnetic hyperthermia/radionuclide therapy, while radiolabeled with Tc-99m could be used in diagnostic imaging.

ACS APPLIED MATERIALS & INTERFACES

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