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The Instituto de Ciencia de Materiales de Madrid (ICMM) is an institute of the Consejo Superior de Investigaciones Cientificas (CSIC) (Spanish National Research Council) founded in December 1986, that belongs to the Area of Science and Technology of Materials, one of the eight Areas in which the CSIC divides its research activities.


Our mission is to create new fundamental and applied knowledge in materials of high technological impact, their processing and their transfer to the productive sectors at local, national and European scales (the true value of materials is in their use), the training of new professionals, and the dissemination of the scientific knowledge.

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Forthcoming Events


Revealing the fine structure of Andreev bound states in hybrid nanowires
Alfredo Levy Yeyati   read more


Fabricación de nanodispositivos electrónicos de materiales bidimensionales mediante la nanolitografía de oxidación local
Arancha Iglesias del Dago  read more


Exotic stationary states in ac-driven open quantum systems: Breakdown of the Floquet-Gibbs distribution
Georg Engelhardt  read more

Citric juice-mediated synthesis of tellurium nanoparticles with antimicrobial and anticancer properties

David Medina Cruz, William Tien-Street, Bohan Zhang, Xinjing Huang, Ada Vernet Crua, Alfonso Nieto-Argüello, Jorge L. Cholula-Díaz, Lidia Martínez, Yves Huttel, María Ujué González, José Miguel García-Martíne and Thomas J. Webster

Bacterial infections and cancer are two of the most significant concerns that the current healthcare system should tackle nowadays. Green nanotechnology is presented as a feasible solution that is able to produce materials with significant anticancer and antibacterial activity, while overcoming the main limitations of traditional synthesis. In the present work, orange, lemon and lime extracts were used as both reducing and capping agents for the green synthesis of tellurium nanoparticles (TeNPs) using a microwave-assisted reaction. TeNPs showed a uniform size distribution, and rod- and cubic-shapes, and were extensively characterized in terms of morphology, structure and composition using TEM, SEM, XPS, XRD, FTIR and EDX analysis. TeNPs showed an important antibacterial activity against both Gram-negative and -positive bacteria in a range concentrations from 5 to 50 μg mL−1 over a 24-hour time period. Besides, nanoparticles showed an anticancer effect towards human melanoma cells over 48 hours at concentrations up to 50 μg mL−1. Moreover, the Te nanostructures showed no significant cytotoxic effect towards human dermal fibroblast at concentrations up to 50 μg mL−1. Therefore, we present an environmentally-friendly and cost-effective synthesis of TeNPs using only fruit juices and showing enhanced and desirable biomedical properties towards both infectious diseases and cancer.

Green Chemistry, 2019

Scanning Electron Microscopy (SEM) image of OR-TeNPs (A, D), LEM-TeNPs (B, E) and LIM-TeNPs (C, F). The characteristic morphology of the nanostructures was observed using SEM. The upper images (A–C) correspond to secondary electrons micrographs and show the morphology of the obtained structures, while the lower ones (D–F) are taken with back-scattered electrons and provide compositional contrast. The scale bar is the same for all images (500 nm).

ICMM-2019 - Sor Juana Inés de la Cruz, 3, Cantoblanco, 28049 Madrid, Spain. Tel: +34 91 334 9000. info@icmm.csic.es