Towards an active bypass for neural reconnection (ByAxon, Grant Agreement No. 737116):
Research coordinator: Rodolfo Miranda (IMDEA-Nanociencia)
Research leader of the CSIC team: María Concepción Serrano López-Terradas
Total amount (CSIC+SESCAM): 453,193.75 €. Period: 2017-2020
In close collaboration with national and international research institutions of scientific excellence such as the IMDEA-Nanociencia (Spain, coordinator), the International School for Advanced Studies in Trieste (Italy), the Centre National de la Recherche Scientifique (France), the Servicio de Salud de Castilla-La Mancha (Spain) and the company mfd Diagnostics (Germany), this project focuses on the design and development of a novel prototype based on sensors and electrodes fabricated by last regeneration Nanotechnology techniques and able to reconnect neural circuitries through the injured spinal cord.

Design and development of a bioactive 3D biomaterial made of graphene oxide and functionalized for the treatment of injured spinal cord (MAT2016-78857- R):
Research leader: María Concepción Serrano López-Terradas
Total amount: 121,000.00 €. Period: 2016-2019
Following with the research topic consolidated with the project CP13/00060 associated to the Miguel Servet I contract of María Concepción Serrano at the Hospital Nacional de Parapléjicos (funded by ISCIII-MINECO- FEDER from 2014 to 2016), this project focuses on the design and development of a bioactive 3D biomaterial based on reduced graphene oxide and able to efficiently promote neural repair responses in the injured spinal cord by means of a significant functional recovery.

Magnetic nanoparticles for environment and health applications, PIE 201760E007, Entidad financiadora: Consejo Superior de Investigaciones Científicas, Entidades participantes:  ICMM (CSIC),  Duración,  desde: Enero 2017 -Dic. 2019, Investigador responsable: Dr. Puerto Morales, Total: 65.634 €

Single-core and multi-core magnetic nanocrystals for biomedical applications (MAGO):
Research leader : Sabino Veintemillas Verdaguer
Total Amount . 181.500€ Period: 2015-2017
This project consists in a detailed and systematic study of the properties of iron oxide magnetic nanocrystals (for its low toxicity) with particle sizes greater than 15 nm (to neglect surface effects) and smaller than 30 nm (to avoid the multidomain formation) forming single and multi core nanostructures, in powder form and in colloidal dispersion. The relationship among the microstructure (crystal size, number of magnetic cores, coating thickness) nature of the magnetic material (magnetite-maghemite, ferrihydrite and core-shell hybrid inorganic  materials), magnetic properties and the applicability of these colloids in Biomedicine will be studied.
The pursued results are the preparation of colloids formed by nanostructures single and multi core of magnetic nanocrystals optimized for: (1) Drug delivery (2)  Magnetothermia and (3) Contrast agents for medical imaging by magnetic resonance (MRI) and magnetic particle imaging (MPI). In this project the material properties such as magnetophoresis, heating capacity in the presence of an alternating field and relaxivity of water protons in the presence of the particles by nuclear magnetic resonance (NMR) will be evaluated in vitro before its interaction with biological entities. This will allow us to make a selection of the best materials prior to in vitro and in vivo tests or before the scaling of the synthesis.

NanoMag: Nanometrology Standardization Methods for Magnetic Nanoparticles:
Research Leader: Morales Herrero, Mª del Puerto
Financing Agency: European Union
Total amount: 520.047 € Period: 2013-2017
The NanoMag project is to improve and redefine existing analyzing methods and in some cases, to develop new analyzing methods for magnetic nanostructures. Using improved manufacturing technologies we will synthesize magnetic nanoparticles with specific properties that will be analyzed with a multitude of characterization techniques (focusing on both structural as well as magnetic properties) and bring the experimental results together to obtain a self-consistent picture which describes how structural and magnetic properties are interrelated. This extensive survey will be used to define standard measurements and techniques which are
necessary for defining a magnetic nanostructure and quality control. NanoMag brings together Europe’s and internationally leading experts in; manufacturing of magnetic single-core nanoparticles and magnetic multi-core particles, analyzing and characterization of magnetic nanostructures and national metrology institutes. In the consortium we have gathered partners within research institutes, universities and metrology institutes, all carrying out front end research and developing applications in the field of magnetic nanoparticles.

AXA research fund Project : “Tracking of magnetic nanoparticle biodistribution”. The central aim of this project is to characterise the biodistribution of magnetic nanoparticles for cancer treatment after intravenous systemic administration and their degradation over time. Outcomes from this project will identify the risk of exposure to new technologies, in particular to nanotechnology, which is one of the research priorities of the Biomedical Risk section from the Life Risks eligible research field of the AXA Research Fund.

IronM@N (MAT2011-23641) “Multifunctional nanostructures based on iron oxide” (Spanish Science and Innovation Ministry). The aim of this proposal is to develop versatile preparation routes for a better control of the crystallochemical and structural factors that govern the properties of materials in which at least an iron oxide phase is a basic component. We are interested in applications (biomedical and water splitting) in which good crystallinity, good morphology control, good adsorption capabilities and sizes of the primary units within the nanoscale are required. Entidad financiadora: Ministerio de Economía y competitividad, Entidades participantes:  ICMM (CSIC),  Duración,  desde: 2011- 2015, Investigador responsable: Dr. M.P. Morales, Total: 230.000 €

MULTIFUN (C-NMP/0878) Multifunctional Nanotechnology for selective detection and Treatment of cancer”, FP7-NMP-2010-LARGE-4;  262943-2  MULTIFUN  CP-IP

NANOBIOMAGNET (S2009/MAT-1726) Fundamentos y aplicaciones de moleculas, nanopartículas y nanoestructuras (Madrid Community).

MULTIPLAB (MAT2008-01489/NAN):”Preparation of multifunctional nanoplatforms for bioimaging” (Spanish Science and innovation Ministry). The main objective of the present project is to obtain new multifunctional magnetic nanoplatforms based on Fe-Si-Bi by thermal decomposition and laser pyrolysis, and to develop new colloidal processing routes such as coating with inorganic compounds or encapsulation into liposomes to optimize the performance of such materials as molecular probes for different medical imaging techniques than MPI.

BONSAI (LSHB-CT-2006-037639): “Bio-imaging with smart functional nanoparticles”. The overall objective of this proposal was the development of novel multifunctional nanoparticles (NPs) based on Si and Fe by laser pyrolysis technique with tailored optical and magnetic properties for visualizing complex cellular structures (in tissues and organs), receptors, tumor cells and masses by ultrasensitive bio-imaging techniques.

NANOMAGNET (S-0505/MAT/0194): “Magnetic nanostructures: Preparation, properties and biomedical and technological applications” (Madrid Community).Study of the interaction mechanism of magnetic nanoparticles and cells and the effect of the particle nature, size and coating on it.

MAGICO (NAN2004-08805-C04-01) “Magnetic nanocomposites for biomedical applications” (Spanish Science and Innovation Ministry). The aim of this proposal was to develop state-of-the-art synthetic routes that could allow a rigorous microstructural control to obtain nanoparticulate magnetic materials with adequate composition and properties (magnetic, colloidal and chemical) to be used in the biotechnology field in both in vitro (chemical separation) and in vivo applications (magnetic resonance imaging and suppression of malignancy). In particular, aerosol-assisted routes (laser and conventional pyrolysis) and thermal decomposition of precursors in the presence of surfactants were used to obtain materials in a reliable and predictable way. synthesis techniques rather than laser pyrolysis (<5 nm) but can benefit from the expertise in nanoparticle dispersing.

Instituto de Ciencia de Materiales de Madrid, CSIC